ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer

Inclusion Criteria:

* completely resected, histologically confirmed adenocarcinoma of the colon or rectum
* patients, who have completed adjuvant chemotherapy 4-16 weeks prior to randomization
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Age ≥18 years
* adequate hematologic functions \<=28d prior to randomization
* able to perform endurance exercise according to protocol
* ability to perform ergometry in order to assess physical capability at the discretion of the investigator
* signed informed consent prior to randomization

Exclusion Criteria:

* significant comorbid conditions precluding participation in a physical activity program (investigators decision)
* disabled patients unable to participate in the physical activity program
* Regular (3-times a week) vigorous physical activity of \>150 minutes (type of physical activity: bicycling, cross walking (cross trainer), jogging, walking at a brisk pace, nordic walking, cross country skiing) within the last year before diagnosis of colorectal cancer
* patients unwilling to complete endurance exercise or complete all questionnaires related to the study
* past or current history of other malignant neoplasms other than colorectal cancer in the last 5 years except basal cell carcinoma of the skin and/or in situ carcinoma of the cervix
* clinically significant cardiovascular disease
* left bundle branch block
* current study with chemotherapy or radiation
* current pregnancy or plans to become pregnant within the next 3 years